The paper examines different approaches to Scripture in general, and exegetical uses of the Book of Psalms in particular, in early Rūm Orthodox (Melkite) texts. It singles out general statements relating to Scripture and explains them both in terms of reception of the Patristic heritage and as a message delivered to an audience in a specific context. It also discusses the authors’ conception of the Hebrew text of the Bible. Finally, the paper investigates the uses of the Psalms’ quotations in the analyzed texts, often used to prove Christian doctrines as expressed in the New Testament.